LDN & Painkillers Like Vicodin
Question: Is it safe to take vicodin while taking 3mg naltrexone? I have managed to fracture my right arm and was prescribed vicodin for pain at the hospital. They were aware of my taking naltrexone daily but only had knowledge of the 50 mg dose.The drug label says hydrocodone/apap 5/500 tab generic for vicodin 5/500 tablet.
Answer: LDN is NOT to be used when any opioid is being used.
Vicodin is a potent opioid.
The dose is not as important as one might think.
We’ve heard of serious problems arising even when the 3.0mg is use at the same time as an opioid.
Short and simple: if you use opioids, don’t use LDN. If you use LDN, don’t use opioids.
The following is taken from TheCompounder.com/msnaltrexone.php
Cautionary warnings: Because naltrexone blocks opioid receptors throughout the body for several hours, people using narcotic medication (such as codeine or morphine) should not take naltrexone simultaneously. It should probably not be taken during pregnancy.
Full-dose naltrexone (50mg) carries a cautionary warning against its use in those with liver disease. This warning was placed because of adverse liver effects that were found in experiments involving 300mg daily. The 50mg dose does not apparently produce impairment of liver function nor, of course, does the much smaller 3mg dose.
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December, 2nd 2009 at 9:19 am
Since the duration of action of LDN is 5 hours, you can take LDN in the evening and Vicodin or prednisone (up to 10 mg) in the morning if needed. You shouldn’t take LDN and Vicodin at the same time, as the LDN will cancel the Vicodin and waste valuable pain medication.
December, 2nd 2009 at 9:38 am
Prednisone is not an issue. It isn’t an opioid. Professionally, I would not recommend that anyone could take naltrexone of any strength – with Vicodin of any strength.
January, 5th 2010 at 1:32 am
Mike,
I’m on 2nd week of LDN 3mg. but also taking 12 1/2 mg. prednisone daily (down gradually over 5 years from 100 mg.!!!) I’ve read that the prednisone will cancel out the LDN & viceversa.
So I’m trying the LDN every other day and 10 mg. of prednisone on the LDN days as far apart as I can (10-12 hours).
I am concerned that the prednisone may be diminished because I’m having a LOT more pain & inflammation but also quit taking tramadol for pain AND plaquinel about 2 weeks ago to take the LDN.
What you’re saying seems to make sense but wondering if you have any resources you’ve found for this info.
THANKS so much for your input!
January, 5th 2010 at 1:34 am
P.S. on my “off LDN days” I’m taking 1 dose of 10 mg prednisone AND about 12 hours later, 5 1/2 mg prednisone…
January, 5th 2010 at 8:44 am
ANother comment regarding Mike Doyle’s note. We have experience where 3mg of naltrexone dose more than merely block the pain relieving effects of Vicodin. A local doctor reported that his patient actually experience withdrawal symptoms after using LDN. My final advice is DO NOT use LDN if you are using opioids – or if you have been using them recently.